The Effect of Cognitive Rehabilitation on Epileptic Pateints Under Treatment

Gulhane Training and Research Hospital

Status: Completed

Conditions: Epilepsy; Cognitive Dysfunction

Treatments: Other: cognitive rehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT06643559

CR ethics commitee 2022/84

Details and patient eligibility

About

It is clear that studies on cognitive rehabilitation in epilepsy patients mostly focus on patients undergoing epilepsy surgery and are largely classified according to the type of epilepsy. The main purpose of this study is to determine whether cognitive impairments associated with antiepileptic drugs develop in epilepsy patients using neuropsychological tests and event-related potentials, and if such an impairment is present, to investigate whether cognitive rehabilitation is beneficial.

Full description

Patients who were planned to start monotherapy were first included in the study by performing a face-to-face MoCA test. After the MoCA test, experienced neurologists measured event-related potentials, including P300 and N200 potentials and N2P3 amplitudes, in the electrophysiology laboratory. Patients for each drug were randomly assigned to the no cognitive rehabilitation group (A) or the cognitive rehabilitation group (B). At the end of the second month, MoCA test and event-related potential measurements were performed again in both groups, and the results were analyzed statistically.

Enrollment: 368 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Newly diagnosis of epilepsy, -
• Before monotherapy had started

Exclusion criteria

• diagnosis of psychogenic non-epileptic seizures,
• epileptic patients currently receiving antiepileptic drugs,
• epileptic patients exhibiting cognitive dysfunction
• epileptic patientswith dementia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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368 participants in 2 patient groups

patients with cognitive rehabilitation

Active Comparator group

Description:

Patient which have started antiseizure monotherapy plus have been included cognitive rehabilitation programme.

Treatment:

Other: cognitive rehabilitation

Patients Without Cognıtıve Rehabilitation

No Intervention group