The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease (ECLIPSE)

The University of The West Indies

Status and phase: Completed; Phase 1

Conditions: Coronary Artery Disease

Treatments: Drug: Colchicine 0.5 MG oral tablet twice daily

Study type: Interventional

Funder types: Other

Identifiers

NCT06567678

CREC-SA2525/02/2024

Details and patient eligibility

About

The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties. This present study aims to explore the effects of colchicine on platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy.

Full description

Recent landmark clinical trials on the use of colchicine in patients with chronic coronary artery disease has led to its implementation as an FDA approved drug for secondary prevention in patients with coronary artery disease. Colchicine exerts a range of anti inflammatory effects which plays a major role in reduction of atherosclerosis and prevention cardiovascular events. This current study aims to investigate the effect of colchicine on platelet reactivity in patients with stable coronary artery disease already on dual anticoagulants.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with stable coronary artery disease.
• Patients older than 18 years of age.
• Patients currently on dual anti platelets, aspirin and clopidogrel

Exclusion criteria

• Patients already on colchicine

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

22 participants in 1 patient group

Colchicine 0.5mg po bd

Experimental group

Description:

Patients with coronary disease taking Colchicine 0.5mg twice-daily orally for two weeks

Treatment:

Drug: Colchicine 0.5 MG oral tablet twice daily