The Effect of Cold Exposure on Energy Expenditure

Maastricht University

Status: Completed

Conditions: Cold Exposure

Treatments: Other: Cold exposure

Study type: Interventional

Funder types: Other

Identifiers

NCT05107570

WEU

Details and patient eligibility

About

Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.

Enrollment: 26 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Signed informed consent
• Western European origin or of Siberian origin
• BMI between 18.5 and 35 kg/m2
• Generally healthy (determined by dependent physician)

Exclusion criteria

• Smoking
• Active, uncontrolled cardiovascular disease or cancer
• Raynaud's disease
• Participation in another biomedical study within 1 month before the first study
• Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
• Medication use known to hamper subject's safety during study procedures
• Abuse of alcohol or drugs

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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26 participants in 2 patient groups

Cold exposure applied to Western European individuals

Other group

Description:

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched Siberian individuals.

Treatment:

Other: Cold exposure

Cold exposure applied to Siberian individuals

Other group

Description:

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched European individuals.

Treatment:

Other: Cold exposure