The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

Johns Hopkins University

Status and phase: Completed; Phase 3

Conditions: Lung Transplant Recipients

Treatments: Device: Celsior Cold Storage Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT00284726

00-10-25-03

Details and patient eligibility

About

The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Full description

The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion criteria