The Effect of Coleus Forskohlii Extract on the Risk Factors of Metabolic Syndrome

Olive Lifesciences

Status and phase: Unknown; Phase 3

Conditions: Obesity; Metabolic Syndrome

Treatments: Other: Placebo; Dietary Supplement: Coleus forskohlii extract

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT02143349

ACTRN12614000305628

Details and patient eligibility

About

Coleus forskohlii extract contains the bioactive compound, forskolin. Preliminary studies have shown that forskolin can increase fat metabolism thus reduce fat accumulation in both animals and humans. It has been suggested that forskolin may also suppress appetite thus reduce energy intake and results in weight loss. This study will evaluate the appetite suppressant properties of Coleus forskohlii extract. In addition the effect on central obesity and risk factors of metabolic syndrome will also be investigated.

Enrollment: 50 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Both Australian males and females, age 20-60 years, Overweight or obese (BMI >25), waist circumference of > 94 cm (male), waist circumference of >80 cm (female)

Exclusion criteria

• Cigarette smoker, hypertension, all types of heart, liver and kidney disease, pregnancy, lactating, Type 1 diabetes and weight loss medication.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups, including a placebo group

Coleus forskohlii extract

Experimental group

Description:

Ingestion of 250 mg capsle (Coleus forskohlii extract) twice a day for 12 weeks

Treatment:

Dietary Supplement: Coleus forskohlii extract

Placebo

Placebo Comparator group

Description:

Ingestion of 250 mg capsule (placebo) twice a day for 12 weeks

Treatment:

Other: Placebo