The Effect of Continuous Sipping of a Glucose Solution on Markers of Oxidation in Men and Women (AOGI)

University of Toronto

Status: Completed

Conditions: Diabetes; Cardiovascular Disease

Treatments: Dietary Supplement: Glucose sipping plus 1g vitamin C; Dietary Supplement: Glucose bolus plus 1g vitamin C; Dietary Supplement: glucose bolus; Dietary Supplement: Glucose sipping

Study type: Interventional

Funder types: Other

Identifiers

NCT01440790

25401TW

Details and patient eligibility

About

The objective of this study is to determine the effect of reducing the rate of glucose absorption on oxidative stress after eating and to compare it with the effects of vitamin C. The hypothesis is that reducing the rate of glucose absorption will reduce oxidative stress to a similar extent as 1g vitamin C.

Full description

Recently, much attention has been paid to evidence that abnormalities of the postprandial state (hyperglycemia) are important contributing factors to the development of chronic disease. This attention has increased interest in the role low glycemic index (GI) foods could potentially play in preventing postprandial oxidative burst/stress. GI is a means by which to categorize carbohydrate according to their postprandial glycemic response. Low GI foods promote slow intestinal absorption, prolonged and less pronounced postprandial glycemia, may decrease risk of chronic disease, as well as provide metabolic benefit to people living with glucose abnormalities as well as those with normal glucose. Few studies have been conducted looking at the potential relationship between GI and oxidation and are limited by dietary/lifestyle confounders. The proposed study has been developed to eliminate these confounders. Hypotheses (3): 1. Sipping glucose slowly over 3h will result in less oxidative stress than ingesting the same amount of glucose as a bolus over 5min. 2. Sipping glucose will reduce oxidative stress to the same extent as 1g of oral vitamin C. 3. The effect of sipping glucose on oxidative stress will occur sooner than that of vitamin C.

Enrollment: 18 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy males or females
• 18 to 75 years

Exclusion criteria

• diabetes
• recent hospitalization

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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18 participants in 4 patient groups, including a placebo group

Glucose bolus alone

Placebo Comparator group

Description:

50g glucose dissolved in water and consumed within 5 minutes.

Treatment:

Dietary Supplement: glucose bolus

Glucose sipping alone

Experimental group

Description:

50g glucose dissolved in water and consumed gradually over 3 hours.

Treatment:

Dietary Supplement: Glucose sipping

Glucose bolus plus 1g vitamin C

Active Comparator group

Description:

50g glucose dissolved in water and consumed in 5 minutes with 1g vitamin C

Treatment:

Dietary Supplement: Glucose bolus plus 1g vitamin C

Glucose sipping plus 1g vitamin C

Experimental group

Description:

50g glucose dissolved in water and consumed gradually of 3 hours. In addition 1g vitamin C will be taken with the first mouthful of glucose solution.

Treatment:

Dietary Supplement: Glucose sipping plus 1g vitamin C