The Effect of Cord Blood Serum Eyes Drops Administer in Patients With Severe Keratopathy Related to EGFR-I Treatment

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Enrolling

Conditions: Dry Eye

Treatments: Drug: administration cord blood based eye drops, standardized to the deliver BDNF.

Study type: Interventional

Funder types: Other

Identifiers

NCT06830551

F35F22000080001 (Other Grant/Funding Number)

OFTAFONTANA_DED_EGFR-I

Details and patient eligibility

About

The study aim to evaluate the efficacy of cord blood eye drops in the healing of the damaged corneal epithelium.

Full description

Patients undergoing treatment with EGFR inhibitor for lung cancer might develop corneal damage.

The study aims to evaluate the healing of corneal epithelium by administering cord blood eye drops for one month.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age over 18 years
• oncology and advanced cancer patients who have EGFr mutation and who require treatment with antiEGFr drugs
• signing of informed consent

Exclusion criteria

• Patients who are unable to store/administer the CSCO independently, or with the help of care-givers.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

eye drops derived from cordonal blood serum

Experimental group

Description:

patients who are given eye drops

Treatment:

Drug: administration cord blood based eye drops, standardized to the deliver BDNF.