The Effect of CPAP on Lung Hyperinflation in Patients With OSA

University Hospital Olomouc

Status: Completed

Conditions: Obstructive Sleep Apnea

Treatments: Device: Continuous Positive Airway Pressure therapy

Study type: Observational

Funder types: Other

Identifiers

NCT04084899

OSAS_bodypletysmo

Details and patient eligibility

About

Assessment of the lung hyperinflation by bodypletysmography in patients with obstructive sleep apnoea treated with continuous positive airway pressure therapy.

Full description

Rationale:

Obstructive sleep apnoea (OSA) is characterized by repetitive closure of upper airways leading to apnoea (complete airflow cessation) or hypopnoea (airflow limitation > 50% + blood oxygen desaturation > 3% or airflow limitation > 30% blood oxygen desaturation > 4%). The prevalence of lung hyperinflations in sleep apnoea patients and effect of continuous positive airway pressure (CPAP) therapy is not known.

Process:

Subjects included in the study will be obstructive sleep apnoea (OSA) patients diagnosed by respiratory polysomnography performed in the Sleep Laboratory, Department of Respiratory Medicine, University Hospital Olomouc.

Bodypletysmography will be performed in the time of OSA diagnosis and after 3 months of CPAP therapy.

Data will be statistically evaluated after completion of the target number of subjects.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obstructive sleep apnoea syndrome indicated for CPAP therapy (Apnoea- Hypopnoea index ˃ 15)

Exclusion criteria

• • Bilevel positive airway pressure therapy
• Total lung capacity < 80% lower limit of normal values
• Obstructive ventilatory disorder
• Change in body weight ˃ 10%
• Change in smoking status

Trial design

50 participants in 1 patient group

Continuous Positive Airway Pressure

Description:

Patient treated with continuous positive airway pressure

Treatment:

Device: Continuous Positive Airway Pressure therapy