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The Effect of Creatine on Muscle Loss (CML)

Maastricht University Medical Centre (MUMC) logo

Maastricht University Medical Centre (MUMC)

Status

Completed

Conditions

Muscle Loss

Treatments

Other: Creatine supplementation
Other: Placebo supplementation

Study type

Interventional

Funder types

Other

Identifiers

NCT01894737
METC 13-3-023

Details and patient eligibility

About

The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.

Full description

Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determined and muscle biopsies will be collected before and immediately after immobilisation. A week after the cast is removed we will assess any differences in recovery between intervention groups.

Enrollment

30 patients

Sex

Male

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Male
  • Aged from 18-35 years
  • 18.5 < BMI < 30 kg/m2

Exclusion criteria

  • (Family) history of thrombosis
  • Smoking
  • Recent surgery
  • Performing regular resistance training more than once per week in the past year
  • Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
  • Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
  • All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
  • Use of anti-coagulants
  • Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

30 participants in 2 patient groups, including a placebo group

immobilisation and placebo
Placebo Comparator group
Description:
Seven days of one-legged knee immobilisation with placebo supplementation
Treatment:
Other: Placebo supplementation
immobilisation and creatine
Experimental group
Description:
Seven days of one-legged knee immobilisation with creatine supplementation
Treatment:
Other: Creatine supplementation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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