The Effect of Creatine on Muscle Loss (CML)
Status
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Treatments
Details and patient eligibility
About
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.
Full description
Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determined and muscle biopsies will be collected before and immediately after immobilisation. A week after the cast is removed we will assess any differences in recovery between intervention groups.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Male
- Aged from 18-35 years
- 18.5 < BMI < 30 kg/m2
Exclusion criteria
- (Family) history of thrombosis
- Smoking
- Recent surgery
- Performing regular resistance training more than once per week in the past year
- Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
- Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- Use of anti-coagulants
- Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
Trial design
Primary purpose
Allocation
Interventional model
Masking
30 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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