The Effect of Curcumin for Treatment of Cancer Anorexia-Cachexia Syndrome in Patients With Stage III-IV of Head and Neck Cancer (CurChexia)

Phramongkutklao College of Medicine and Hospital

Status and phase: Completed; Phase 2

Conditions: Head and Neck Neoplasms; Cancer Cachexia; Head and Neck Cancer

Treatments: Dietary Supplement: Curcumin; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04208334

R119h/61

Details and patient eligibility

About

A study of Curcumin to prevent cancer anorexia and cachexia Syndrom in locally advance and advance stage head and neck cancer (stage III, IV)

Enrollment: 20 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Head and neck cancer stage III-IV
• Cancer anorexia cachexia syndrome by 2011 Cancer cachexia an International Consensus
• Enteral feeding with Nasogastric Tube or Gastrostomy
• ECOG 0-2
• Normal Bone marrow, kidneys, and liver function
• Normal function of enteral digestion and absorption

Exclusion criteria

• Pregnancy
• History of allergy to Curcumin or herbal medicine
• History of Herbal medicine used
• History of Billiary of obstruction
• History of Antiplatelete or anticoagulant.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

20 participants in 2 patient groups, including a placebo group

Curcumin

Experimental group

Description:

Curcumin 4000mg/day x 60 days

Treatment:

Dietary Supplement: Curcumin

Placebo

Placebo Comparator group

Description:

Placebo x 60 days

Treatment:

Other: Placebo