The Effect of Daily Mango Intake on Cardiovascular Health

University of California (UC) Davis

Status

Completed

Conditions

Cardiovascular Risk Factor

Treatments

Other: No intervention

Other: Mango

Study type

Interventional

Funder types

Other

Identifiers

NCT03203187

894860

Details and patient eligibility

About

In the current proposal the investigators seek to evaluate the acute and short-term effects of mango intake on vascular and platelet function in postmenopausal women between 50 and 70 years old.

Our aims are 1) to determine if two weeks of daily mango intake will result in favorable changes in measures of vascular function, as measured using peripheral arterial tonometry (PAT) and platelet reactivity, in overweight and obese postmenopausal women. 2) to determine if two weeks of daily mango intake will change the fermentation capacity of gut microbiota.

Investigators hypothesize that the daily intake of 330 grams of mango (2 cups) will significantly increase PAT while reducing platelet aggregation after 2 hours and two weeks of daily intake.

Enrollment

21 patients

Sex

Female

Ages

50 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Postmenopausal female: 50-70 years
Women: lack of menses for at least one year and FSH 23-116.3 mlU/mL
Subject is willing and able to comply with the study protocols.
Subject is willing participate in all study procedures
BMI 25.0 - 40 kg/m2
Weight ≥ 110 pounds

Exclusion criteria

BMI ≥ 40 kg/m2
Dislike or allergy for mango
Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
Alcohol consumption > 3 drinks/week (i.e. 1 bottle of beer, ½ glass of wine, and 1 shot of hard liquor)
Fruit consumption ≥ 2 cups/day
Vegetable consumption ≥ 3 cups/day for females
Fatty Fish ≥ 3 times/week
Coffee/tea ≥ 3 cups/day
Dark chocolate ≥ 3 oz/day
Self-reported restriction of physical activity due to a chronic health condition
Self-reported chronic/routine high intensity exercise
Self-reported diabetes
Blood pressure ≥ 140/90 mm Hg
Self-reported renal or liver disease
Self-reported heart disease, which includes cardiovascular events and Stroke
Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
Abnormal Liver, CBC or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.
Self-reported cancer within past 5 years
Self-reported malabsorption
Currently taking prescription drugs or supplements, other than thyroid medication.
Use of multi-vitamin and mineral other than a general formula of vitamins and minerals that meet the RDA
Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
Indications of substance or alcohol abuse within the last 3 years
Screening LDL ≥ 190 mg/dl for those who have 0-1 major risk factors apart from LDL cholesterol (i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].
Screening LDL ≥ 160 mg/dl for those who have 2 major risk factors apart from LDL cholesterol [i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL].

(using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp);

Screening LDL ≥ 130 mg/dl for those who have 2 major risk factors apart from LDL cholesterol [i.e. family history of premature coronary artery disease (male first degree relative < 55 years; CHD in female first degree relative < 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL], and a Framingham 10-year Risk Score 10-20% (using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp).
Current enrollee in a clinical research study.