The Effect of Daily Tamsulosin 0.2mg Administration on Renal Function in Patients With Benign Prostatic Hyperplasia

The Catholic University of Korea

Status

Unknown

Conditions

Chronic Kidney Failure

Prostatic Hyperplasia

Treatments

Drug: Tamsulosin

Study type

Interventional

Funder types

Other

Identifiers

NCT02033798

L201401N2

Details and patient eligibility

About

The purpose of this study is to determine whether medical treatment for bladder outlet obstruction is effective in improvement of glomerular filtration rate and/or proteinuria.

Full description

Urodynamic parameters including maximal flow rate, compliance (infused volume gradient divided by bladder pressure gradient during cystometry), maximal detrusor pressure, bladder outlet obstruction index and Schäfer grade will be checked.

Estimated glomerular filtration rate and urinary protein to creatinine ratio will be checked.

International prostate symptom score will be checked.

Enrollment

34 estimated patients

Sex

Male

Ages

40 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Men with low urinary tract symptoms aged between 40 and 80
Estimated glomerular filtration rate < 60 or evidence of proteinuria
Bladder outlet obstruction index > 40, Schäfer grade 2 or more, maximal flow rate lower than 10 cc/s or postvoid residual urine > 100cc

Exclusion criteria

Bladder outlet obstruction index less than 40, Schäfer grade 0 or 1, maximal flow rate higher than 10 ml/s and postvoid residual urine less than 100cc
Want surgical procedure
Evidence of prostate cancer or bladder cancer
Major depressive disorder, Dementia, Parkinson's disease or neurological deficits
History of pelvic irradiation
Uncontrolled diabetes mellitus or hypertension
Symptomatic orthostatic hypotension