The Effect of Degree of Rice-polishing on Glycaemic Response

Clinical Nutrition Research Centre, Singapore

Status: Completed

Conditions: Diabetes Mellitus; Obesity

Treatments: Other: 6 % polished rice; Other: Glucose Reference 2; Other: Brown Rice; Other: Glucose Reference 3; Other: 9 % polished rice; Other: Glucose Reference 1; Other: 3 % polished rice; Other: 20 % Polished rice

Study type: Interventional

Funder types: Other

Identifiers

NCT04228341

2018/01079

Details and patient eligibility

About

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Full description

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Enrollment: 14 patients

Sex: Male

Ages: 21 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Chinese ethnicity
• Age ≥21 and ≤ 60 years
• Body mass index between 18.5 to 25 kg/m2
• Normal blood pressure =<140/90 mmHg
• Fasting blood glucose <6.0 mmol/L
• In general good health

Exclusion criteria

• Current smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have intolerances or allergies to any foods
• Currently partake in sports at the competitive and/or endurance levels
• Intentionally restrict food intake

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

14 participants in 8 patient groups

Glucose Reference 1

Other group

Description:

Glucose solution 1

Treatment:

Other: Glucose Reference 1

Glucose Reference 2

Other group

Description:

Glucose solution 2

Treatment:

Other: Glucose Reference 2

Glucose Reference 3

Other group

Description:

Glucose solution 3

Treatment:

Other: Glucose Reference 3

Brown Rice

Experimental group

Description:

Cooked brown rice

Treatment:

Other: Brown Rice

3 % polished rice

Experimental group

Description:

Cooked 3 % polished rice

Treatment:

Other: 3 % polished rice

6 % polished rice

Experimental group

Description:

Cooked 6 % polished rice

Treatment:

Other: 6 % polished rice

9 % polished rice

Experimental group

Description:

9 % polished rice

Treatment:

Other: 9 % polished rice

20 % Polished rice

Experimental group

Description:

Cooked 20 % Polished rice (White Rice)

Treatment:

Other: 20 % Polished rice