The Effect of Desflurane on Postopertative Cognitive Dysfunction

Capital Medical University

Status and phase: Unknown; Phase 4

Conditions: Postoperative Delirium; Postoperative Cognitive Dysfunction

Treatments: Drug: Desflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT04541823

00375928

Details and patient eligibility

About

The purpose of this study is to determine the effect of desflurane on postoperative cognitive dysfunction

Full description

Postoperative cognitive dysfunction is a common complication during postoperative period，especially in elderly patients. It is characterized by cognitive decline, inattention and abnormal mental status following surgery. The presence of postoperative cognitive dysfunction is independently associated with poor recovery, increased hospital length of stay and increased mortality.

Desflurane is a widely used volatile anesthetic, associated with shorter emergence times than other volatile anesthetics. This study aims to access the effect of desflurane in preventing postoperative cognitive dysfunction.

Enrollment: 100 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Written consent given
• 2. Scheduled to undergo elective non-cardiac surgeries under general anesthesia
• 3. ASA Physical Score I-III

Exclusion criteria

• 1. Patients with a history of neurological disease, such as Alzheimer disease.
• 2. Patients with a history of psychiatric disease
• 3. Patients with a medication history of antipsychotic drugs.
• 4. Unable to complete neuropsychological testing including patients with severe visual or hearing impairment.
• 5. Patients with preoperative delirium.
• 6. Patients who have severe adverse events, such as cardiac arrest.
• 7. Patients who preoperative MMSE score are below 20;
• 8. Patients who undergo second operation in a short period.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Desflurane

Experimental group

Description:

Patients allocated to this arm will receive desflurane during the maintenance of anesthesia.

Treatment:

Drug: Desflurane

Propofol

Placebo Comparator group

Description:

Patients allocated to this arm will receive propofol during the maintenance of anesthesia

Treatment:

Drug: Propofol