The Effect of Dexamethasone Added to Bupivacain in Nasal Surgery

Ataturk University

Status and phase: Completed; Phase 4

Conditions: Nasal Surgery

Treatments: Drug: Bupivacaine; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT03036605

Ataturk University

Details and patient eligibility

About

Nasal packing is frequently applied after nasal surgery. Nasal packing reduces epistaxis, prevents septal hematoma and stabilizes nasal septum. Nasal mucosa is quite sensitive to pain, therefore the most common problems after surgery are postoperative pain and anxiety during removal of the nasal packing. Lots of methods have been tried to control this pain (non-steroidal anti-inflammatory drugs, nerve blockade with long-acting local anesthetics, local anesthetics infiltration into nasal packing).

Glucocorticoids have been used as an adjuvant in the management of acute postoperative pain. Perineural dexamethasone as an adjuvant for the single-injection nerve block can prolong analgesia and reduce opioid-requiring after surgery. Furthermore dexamethasone reduces postoperative nausea and vomiting incidance.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologist's physiologic state I-II patients undergoing nasal surgery

Exclusion criteria

• chronic pain
• bleeding disorders
• renal or hepatic insufficiency
• patients on chronic non-steroidal anti-inflammatory medications
• emergency cases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Group Bupivacaine

Active Comparator group

Description:

4 ml %0.5 bupivacaine and 1 ml %0.9 NaCl infiltration into nasal packing to both sides

Treatment:

Drug: Bupivacaine

Group Bupivacaine+Dexamethasone

Active Comparator group

Description:

4 ml %0.5 bupivacaine and 4mg(1 ml) dexamethasone infiltration into nasal packing to both sides

Treatment:

Drug: Dexamethasone

Drug: Bupivacaine