The Effect of Dexmedetomidine for Emergence Cough

Ajou University School of Medicine

Status: Completed

Conditions: Cough

Treatments: Drug: Normal saline; Drug: Remifentanil; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03622502

AJIRB-MED-OBS-18-170

Details and patient eligibility

About

Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

Full description

Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Enrollment: 48 patients

Sex: All

Ages: 19 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia

Exclusion criteria

• predicted difficult airway
• body mass index > 35 kg/m2,
• recent upper respiratory infection
• asthma
• current smoker
• patients using angiotensin converting enzyme-inhibitors
• uncontrolled hypertension

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 2 patient groups

Dexmedetomidine

Experimental group

Description:

Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period

Treatment:

Drug: Dexmedetomidine

Drug: Remifentanil

Remifentanil

Active Comparator group

Description:

Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period

Treatment:

Drug: Remifentanil

Drug: Normal saline