The Effect of Dexmedetomidine for Suprascapular Nerve Block With Axillary Nerve Block

Chuncheon Sacred Heart Hospital

Status and phase

Completed

Phase 4

Conditions

Postoperative Pain

Suprascapular Nerve Block

Arthroscopic Rotator Cuff Repair

Pain Related Cytokine

Dexmedetomidine

Axillary Nerve Block

Treatments

Drug: Saline injection

Drug: Dexmedetomidine injection

Study type

Interventional

Funder types

Other

Identifiers

NCT04398589

2015-20

Details and patient eligibility

About

Suprascapular nerve block (SSNB) is most commonly used for relieving postoperative pain of arthroscopic rotator cuff repair and it can be used in combination with axillary nerve block (ANB). Dexmedetomidine (DEX) is known as a type of alpha agonist which can elongate the duration of regional block. The aim of this study was to compare the results of dexmedetomidine combined with SSNB and ANB with SSNB and ANB alone on postoperative pain, satisfaction, and pain-related cytokines within the first 48 hours after arthroscopic rotator cuff repair.

Forty patients with rotator cuff tears who had undergone arthroscopic rotator cuff repair were enrolled in this single center, double-blinded randomized controlled trial study. Twenty patients were randomly allocated to group 1 and received ultrasound-guided SSNB and ANB using each mixture of 0.5 ml (50 μg) of DEX and 9.5 ml of 0.75% ropivacaine preemptively. The other 20 patients were allocated to group 2 and underwent ultrasound-guided SSNB and ANB alone using a mixture of 0.5 ml of normal saline and 9.5 ml of ropivacaine. The visual analog scale (VAS) for pain and patient satisfaction (SAT) scores were checked within 48 h postoperatively. The plasma interleukin (IL)-6, -8,-1β, cortisol, and serotonin levels were also measured within 48 h postoperatively.

Enrollment

46 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

defined rotator cuff tear on preoperative MRI, which indicated repair
acceptable arthroscopic surgery, including rotator cuff repair
patients >20 years old
acceptable routine regional blocks and patient-controlled analgesia (PCA)

Exclusion criteria

did not undergo arthroscopic rotator cuff repair
stopped PCA before 48 h postoperatively due to side effects
had a concomitant operation for a Bankart lesion
had a history of shoulder operation or fracture
had a concomitant neurological disorder around the shoulder
underwent conversion to open surgery from the arthroscopy
had contraindications for the routine regional blocks used in this study
had an known allergy or hypersensitivity against ropivacaine or dexmedetomidine, including other amino-amide local anesthetics or α2-adrenoceptor agonists.