The Effect of Dexmedetomidine in Intraocular Pressure During Robot-Assisted Laparoscopic Radical Prostatectomy

Yonsei University

Status: Completed

Conditions: Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy

Treatments: Drug: Dexmedetomidine; Drug: saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01898819

4-2013-0195

Details and patient eligibility

About

Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged timeds of pneumoperitoneum. Threrefore we decided to evaluate the effect of dexmedetomidine in intraocular pressure during roboti-assisted laparoscopic radical prostatectomy.

Enrollment: 70 patients

Sex: Male

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ASA class I-II
2. obtaining written informed consent from the parents
3. aged 20-70 years who were undergoing robot- assited laparoscopic prostatectomy

Exclusion criteria

1. eye surgery prevoiusly
2. unstable angina or congestive heart failure
3. concomittant eye disease (glaucoma, diabetic retinophaty, cataract, retinal detachment)
4. high intraocular pressure over 30mmHg after screening test.
5. uncontrolled hypertension (diastolic bp>110mmHg)
6. bradycardia under 60bpm
7. Ventricular conduction abnormality
8. hepatic failure
9. renal failure
10. drug hyperactivity
11. neurological or psychiatric illnesses
12. mental retardation
13. patients who can't read the consent form due to illiterate or foreigner

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

dexmedetomidine

Experimental group

Description:

dexmedetomidine infusion from beginning of the anesthesia to just before returning to horizontal position

Treatment:

Drug: Dexmedetomidine

saline

Placebo Comparator group

Description:

Saline infusion from same time period.

Treatment:

Drug: saline