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The Effect of Dexmedetomidine in Intraocular Pressure During Robot-Assisted Laparoscopic Radical Prostatectomy

Yonsei University logo

Yonsei University

Status

Completed

Conditions

Steep Trendelenburg Position With Penumoperitoneum in Robot Assisted Laparoscopic Prostatectomy

Treatments

Drug: Dexmedetomidine
Drug: saline

Study type

Interventional

Funder types

Other

Identifiers

NCT01898819
4-2013-0195

Details and patient eligibility

About

Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged timeds of pneumoperitoneum. Threrefore we decided to evaluate the effect of dexmedetomidine in intraocular pressure during roboti-assisted laparoscopic radical prostatectomy.

Enrollment

70 patients

Sex

Male

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. ASA class I-II
  2. obtaining written informed consent from the parents
  3. aged 20-70 years who were undergoing robot- assited laparoscopic prostatectomy

Exclusion criteria

  1. eye surgery prevoiusly
  2. unstable angina or congestive heart failure
  3. concomittant eye disease (glaucoma, diabetic retinophaty, cataract, retinal detachment)
  4. high intraocular pressure over 30mmHg after screening test.
  5. uncontrolled hypertension (diastolic bp>110mmHg)
  6. bradycardia under 60bpm
  7. Ventricular conduction abnormality
  8. hepatic failure
  9. renal failure
  10. drug hyperactivity
  11. neurological or psychiatric illnesses
  12. mental retardation
  13. patients who can't read the consent form due to illiterate or foreigner

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

70 participants in 2 patient groups, including a placebo group

dexmedetomidine
Experimental group
Description:
dexmedetomidine infusion from beginning of the anesthesia to just before returning to horizontal position
Treatment:
Drug: Dexmedetomidine
saline
Placebo Comparator group
Description:
Saline infusion from same time period.
Treatment:
Drug: saline

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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