The Effect of Dexmedetomidine on Kidney Function in EVAR (DEVAR)

University of Thessaly

Status: Unknown

Conditions: Dexmedetomidine; Acute Kidney Injury; Endovascular Aortic Repair

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT04766047

Dexmedetomidine in EVAR

Details and patient eligibility

About

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

Full description

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective EVAR under general anesthesia
• adult patients 18- 85 years old
• American society of anesthesiologists (ASA) physical status I - IV

Exclusion criteria

• refusal to participate or sign the informed consent form
• GFR < 50ml/mim
• Bradyarrhythmia <50/min
• Hemodynamic instability
• Known allergy to Dexmedetomidine
• Severe hepatic insufficiency

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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200 participants in 2 patient groups

DEXMEDETOMIDINE AND AKI

Active Comparator group

Description:

The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively.

Treatment:

Drug: Dexmedetomidine

CONTROL AND AKI

No Intervention group

Description:

The patients of the group undergoing EVAR under general anesthesia will not receive dexmedetomidine intraoperatively.