The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal Surgery

Yonsei University

Status: Completed

Conditions: Spinal Stenosis

Treatments: Drug: dexmedetomidine group; Drug: control group

Study type: Interventional

Funder types: Other

Identifiers

NCT02902380

4-2016-0644

Details and patient eligibility

About

Surgical stress induces stress hormone release and sympathetic hyperactivation. Dexmedetomidine has sympatholytic effect and attenuates stress responses. This study investigate the effect of dexmedetomidine on stress responses and autonomic nervous system balance in patients undergoing major spine surgery.

Enrollment: 52 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ
• patient scheduled for major spine surgery

Exclusion criteria

• ASA physical status Ⅳ
• congestive heart failure
• severe hepatorenal disease
• insulin dependent DM(diabetes mellitus)
• cancer or metastasis
• pregnancy
• problem with communication

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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52 participants in 2 patient groups, including a placebo group

Dexmedetomidine Group

Experimental group

Description:

dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to end of surgery

Treatment:

Drug: dexmedetomidine group

Control Group

Placebo Comparator group

Description:

0.9% saline infusion

Treatment:

Drug: control group