The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway

Ajou University School of Medicine

Status and phase: Completed; Phase 4

Conditions: Precedex Effect to Propofol Requirement

Treatments: Drug: Dexmedetomidine; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02284672

AJIRB-MED-CT4-14-296

Details and patient eligibility

About

Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.

Enrollment: 39 patients

Sex: All

Ages: 19 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients for surgery not exceed more than 2 hours requiring general anesthesia

Exclusion criteria

• history of gastroesophageal reflux High grade obesity Predicted diffiicult airway

Trial design

39 participants in 2 patient groups, including a placebo group

control

Placebo Comparator group

Description:

After preoxygenation for 3 minutes, normal saline would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds. After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA.

Treatment:

Drug: Normal saline

dexmedetomidine

Experimental group

Description:

After preoxygenation for 3 minutes, dexmedetomidine would be injected to patient for 10 minute. First, 1% lidocaine 3 ml were given for reducing injection pain of propofol and the settled amount of propofol was injected during 15 seconds. After 90 seconds, other anesthesiologist who did'nt know the injected drug tried to insert LMA.

Treatment:

Drug: Dexmedetomidine