The Effect of Dextrose Prolotherapy on Isokinetic Power in the Treatment of Knee Osteoarthritis

Mustafa Kemal University

Status and phase: Completed; Phase 4

Conditions: Dextrose Prolotherapy Injection; Knee Osteoarthritis; Physical Therapy

Treatments: Combination Product: conventional physical therapy; Drug: Dextrose prolotherapy injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04958213

MustafaKU-KOA-Prolo

Details and patient eligibility

About

Osteoarthritis is a degenerative joint disease characterized by erosion of the articular cartilage, bone hypertrophy at the margins of the joint, subchondral sclerosis, and some biochemical and morphological changes in the synovial membrane and joint capsule. It is the most common joint disease that causes serious morbidity and its prevalence increases with age. It is known that there is a decrease in the muscle strength around the knee in knee osteoarthritis, which creates difficulties in daily living activities.

Prolotherapy is a regenerative treatment method in the treatment of chronic musculoskeletal pain, in which an irritating solution is injected, often hypertonic dextrose, into painful ligament and tendon attachments and adjacent joint spaces.

In this study, it is aimed to investigate the effect of dextrose prolotherapy application in and around the knee on pain, range of motion and knee flexor/extensor muscle strength.

Enrollment: 60 patients

Sex: Female

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged 50-75 years
• 2-3 knee osteoarthritis by Kellgren Lawrence stage
• Knee pain and functional limitation

Exclusion criteria

• Past knee surgery
• Intra articular knee injections in the last six months
• Symptomatic heart and lung disease
• Joint contracture
• History of malignant disease
• Bleeding disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Conventional physical therapy

Other group

Description:

Conventional physical therapy (Hotpack, TENS and Ultrasound) and home exercise program (isometric and isotonic exercises) will be applied to this group for 4 weeks (20 sessions).

Treatment:

Combination Product: conventional physical therapy

Dextrose prolotherapy treatment

Active Comparator group

Description:

This group will be treated with 15% dextrose prolotherapy around and inside the knee, 2 times with a two-week interval, and home exercise program (isometric and isotonic exercises).

Treatment:

Drug: Dextrose prolotherapy injection