The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease

University of Delaware

Status: Completed

Conditions: Endothelial Dysfunction; Kidney Disease, Chronic

Treatments: Dietary Supplement: Beet It Sport Shot; Dietary Supplement: Nitrate-depleted placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04103736

706281-6

Details and patient eligibility

About

The purpose of this study is to examine the effect of acute ingestion of a concentrated beetroot juice supplement on vascular function and exercise capacity in patients with moderate to severe chronic kidney disease

Full description

People with Chronic Kidney Disease (CKD) are at an increased risk of cardiovascular disease. Blood vessel dysfunction and exercise intolerance are common in CKD. Blood vessel dysfunction has been shown to predict future cardiovascular events and decreased physical activity can contribute to an increased risk of cardiovascular disease. Therefore, this study investigates if dietary nitrate from beetroot juice, which has been shown to improve blood vessel function and exercise capacity in other cardiovascular disease pathologies, could be effective at improving these measures in patients with CKD. In a controlled, double blinded trial, stage 3-5 CKD patients will be randomly assigned to receive either beetroot beverage or a placebo and then complete measures of blood vessel function and an exercise test.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stage 3-5 Chronic Kidney Disease

Exclusion criteria

• History of cardiovascular disease
• Current pregnancy
• Uncontrolled hypertension
• Uncontrolled hyperlipidemia
• Current hormone replacement therapy
• Current use of tobacco products
• Current autoimmune disease
• Current hyperkalemia
• Diagnosis of a deep vein thrombosis (DVT) within the last 6 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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15 participants in 2 patient groups, including a placebo group

Beet Juice Supplement

Experimental group

Description:

A single, acute dose of Beet It Sport Shot containing \~12.6mmol naturally occurring dietary nitrates.

Treatment:

Dietary Supplement: Beet It Sport Shot

Placebo juice

Placebo Comparator group

Description:

A single, acute dose of nitrate-depleted Beet It Sport Shot

Treatment:

Dietary Supplement: Nitrate-depleted placebo