The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children

Ajou University School of Medicine

Status and phase: Unknown; Phase 4

Conditions: Inguinal Hernia

Treatments: Drug: Rocuronium; Drug: ketamine 2; Drug: ketamine 1; Drug: ketamine 1.5

Study type: Interventional

Funder types: Other

Identifiers

NCT02646709

AJIRB-MED-CT4-15-153

Details and patient eligibility

About

Rocuronium is suitable for rapid induction within 60-90 seconds and its effect last 24-40 minute after single bolus injection. For outpatient surgery with short operation time, low dose rocuronium is frequently used for rapid recovery at the expense of compromised intubating condition. For better intubating condition, ketamine can be used. However, appropriate dose of ketamine with low dose rocuronium is not established yet. This study, 3 different doses of ketamine with low dose rocuronium will be compared for appropriate intubating condition.

Enrollment: 60 estimated patients

Sex: All

Ages: 2 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class I, II

Exclusion criteria

• upper respiratory infection within 14 days
• anticipated difficult intubation

Trial design

60 participants in 3 patient groups

Ketamine 1

Experimental group

Description:

Ketamine 1 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation.

Treatment:

Drug: ketamine 1

Drug: Rocuronium

Ketamine 1.5

Experimental group

Description:

Ketamine 1.5 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation.

Treatment:

Drug: ketamine 1.5

Drug: Rocuronium

Ketamine 2

Experimental group

Description:

Ketamine 2 mg/kg will be injected during induction. Low dose rocuronium (0.3 mg/kg) will be injected for muscle relaxation.

Treatment:

Drug: Rocuronium

Drug: ketamine 2