The Effect of Different Doses of Remifentanil on Kidney Function During Robot Assisted Prostatectomy - A Retrospective Study

Yonsei University

Status: Unknown

Conditions: Prostate Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02041559

4-2013-0753

Details and patient eligibility

About

Robot assisted prostatectomy reduces the patients' postoperative pain and leads to rapid rehabilitation. But pneumoperitoneum affects the kidney. The increase of stress hormone reduces the glomerular filtration and the vaso-contraction of renal vessels leads the renal ischemia. Remifentanil is analgesics coupled with μ opioid receptor. In high dose of remifentanil, it is associated with κ and δ receptors, which leads to renal protection effect in animal study. Also, remifentanil infusion during anesthesia showed a diuretic effect. The purpose of this study is to investigate the remifentanil effect on renal function during robot assisted prostatectomy.

Enrollment: 1,500 estimated patients

Sex: Male

Ages: 20 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ages > 19 years and < 85 years
• the patients undergoing a general anesthesia for robot assisted prostatectomy

Exclusion criteria

• incomplete record
• history of opioid or steroid using
• solitary kidney
• history of kidney transplantation

Trial design

1,500 participants in 1 patient group

robot assisted prostatectomy

Description:

robot assisted prostatectomy