The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis (AD)

University of California (UC) Davis

Status: Completed

Conditions: Atopic Dermatitis

Treatments: Other: Bleach Bath and Moisturizers

Study type: Interventional

Funder types: Other

Identifiers

NCT02594969

523979

Details and patient eligibility

About

The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate the effects of different moisturizers on the skin barrier of subjects with and without atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin pH, decrease the skin hydration, and increase skin water loss in all study subjects. Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest water to oil ratio will result in improved skin barrier function. Furthermore, the investigators believe there will be a greater improvement in patients with atopic dermatitis.

Full description

The study has two main parts. Subjects in both groups will have one forearm in a dilute bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be measured using different painless devices. The second part of the study involves application of 4 various moisturizers. The change in skin will be measured over a period of time using the non-invasive devices.

Enrollment: 20 patients

Sex: All

Ages: 8 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 8 years to 65 years
• Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC Davis
• Subject/parents/legal guardians able to read and comprehend the study procedure and consent forms.

Exclusion criteria

• Those who are pregnant, prisoners, or cognitively impaired
• Those who do not fit the inclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Healthy Group

Active Comparator group

Description:

These subjects do not have atopic dermatitis and are considered healthy. They will participate in the bleach bath and the moisturizer application.

Treatment:

Other: Bleach Bath and Moisturizers

Atopic Dermatitis Group

Experimental group

Description:

These subjects have atopic dermatitis and are considered healthy. They will participate in the bleach bath and the moisturizer application.

Treatment:

Other: Bleach Bath and Moisturizers