The Effect of Dosage of Caffeine on Intraocular Pressure

Chiang Mai University

Status: Unknown

Conditions: Caffeine Dosage; Intraocular Pressure

Treatments: Other: regular dose coffee; Other: high dose coffee; Other: decaffeinated coffee

Study type: Interventional

Funder types: Other

Identifiers

NCT01793311

OPT-11-03-03A-12-X

Details and patient eligibility

About

The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses.

Eligible subjects will be randomized into three groups:

1. group 1: intake of decaffeinated coffee
2. group 2: intake of coffee with lower caffeine dose
3. group 3: intake of coffee with higher caffeine dose

Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.

Full description

decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine

all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints:

0 minutes (baseline) 30 minutes after intake 60 minutes after intake 90 minutes after intake

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy subjects
• normal central corneal thickness
• normal baseline intraocular pressure

Exclusion criteria

• any ocular disease
• baseline intraocular pressure over 21 mmHg
• central corneal thickness less than 520 microns or more than 540 microns

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups

Group1: Decaffeinated coffee

Sham Comparator group

Description:

contains 0.5-2 mg of caffeine

Treatment:

Other: decaffeinated coffee

Group2: regular dose coffee

Active Comparator group

Description:

contains 91.8 mg of caffeine

Treatment:

Other: regular dose coffee

Group3: high dose coffee

Active Comparator group

Description:

contains 144 mg of caffeine

Treatment:

Other: high dose coffee