The Effect of Dosage of Caffeine on Intraocular Pressure

C

Chiang Mai University

Status

Unknown

Conditions

Caffeine Dosage
Intraocular Pressure

Treatments

Other: regular dose coffee
Other: high dose coffee
Other: decaffeinated coffee

Study type

Interventional

Funder types

Other

Identifiers

NCT01793311
OPT-11-03-03A-12-X

Details and patient eligibility

About

The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses. Eligible subjects will be randomized into three groups: 1. group 1: intake of decaffeinated coffee 2. group 2: intake of coffee with lower caffeine dose 3. group 3: intake of coffee with higher caffeine dose Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.

Full description

decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints: 0 minutes (baseline) 30 minutes after intake 60 minutes after intake 90 minutes after intake

Enrollment

60 estimated patients

Sex

All

Ages

20 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy subjects
  • normal central corneal thickness
  • normal baseline intraocular pressure

Exclusion criteria

  • any ocular disease
  • baseline intraocular pressure over 21 mmHg
  • central corneal thickness less than 520 microns or more than 540 microns

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

60 participants in 3 patient groups

Group1: Decaffeinated coffee
Sham Comparator group
Description:
contains 0.5-2 mg of caffeine
Treatment:
Other: decaffeinated coffee
Group2: regular dose coffee
Active Comparator group
Description:
contains 91.8 mg of caffeine
Treatment:
Other: regular dose coffee
Group3: high dose coffee
Active Comparator group
Description:
contains 144 mg of caffeine
Treatment:
Other: high dose coffee

Trial contacts and locations

1

Loading...

Central trial contact

Damrong Wiwatwongwana, M.D.

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems