The Effect of Drinking-Water pH on the Human Gut Microbiota

The Novo Nordisk Foundation Center for Basic Metabolic Research

Status: Completed

Conditions: Healthy Participants

Treatments: Other: Alkaline drinking-water; Other: Neutral drinking-water

Study type: Interventional

Funder types: Other

Identifiers

NCT02917616

H-15011825

Details and patient eligibility

About

This study evaluates the effect of alkaline (pH=9) versus neutral (pH=9) drinking-water on the gut microbiota of healthy male volunteers.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Non-smoker
• Age 18 - 35 years
• Weight stabile for at least 2 months
• BMI between 20.0 - 27.0 kg/m^2

Exclusion criteria

• Habitual consumption of caloric or artificially sweetened beverages in excess of 1L/week
• Habitual average consumption of alcohol in excess of 7 drinks/week
• Antibiotic treatment within two months of inclusion
• Chronic or acute illness
• Previous abdominal surgery

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Alkaline water

Experimental group

Description:

Two liters (minimum) daily of alkaline drinking-water (pH=9) for 14 days

Treatment:

Other: Alkaline drinking-water

Neutral Water

Active Comparator group

Description:

Two liters (minimum) daily of neutral drinking-water (pH=7) for 14 days

Treatment:

Other: Neutral drinking-water