The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke

Ke Dong, MD

Status: Completed

Conditions: Aphasia

Treatments: Other: real tACS; Behavioral: speech training; Other: sham tACS

Study type: Interventional

Funder types: Other

Identifiers

NCT07347327

Nos.82102648

Details and patient eligibility

About

This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:

1. Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke?
2. Can it improve the integration of auditory information and speech motor control during communication?

Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients.

Participants will:

1. Receive one extra 20-minute session of either real or sham tACS each day for 10 days
2. Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity

Enrollment: 28 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
• Age ranging from 30 to 80 years old;
• Native language is Mandarin or Cantonese;
• Right-handed;
• Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
• Able to cooperate in completing the speech repetition test;
• Normal hearing.

Exclusion criteria

• Currently receiving non-invasive brain stimulation treatment;
• Lesions involving the Broca or STG brain regions;
• History of epilepsy, mental illness,or other neurological or mental disorders;
• Any contraindications for transcranial electrical stimulation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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28 participants in 2 patient groups

real group

Experimental group

Description:

dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

Treatment:

Behavioral: speech training

Other: real tACS

sham group

Sham Comparator group

Description:

sham tACS except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

Treatment:

Other: sham tACS

Behavioral: speech training