The Effect of Early Switching From Intravenous to Oral Antibiotics Therapy

Gia Dinh People Hospital

Status: Completed

Conditions: Skin and Subcutaneous Tissue Infection

Treatments: Procedure: IV-to-PO conversion of antibiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT04781439

50/CN-HĐĐĐ

Details and patient eligibility

About

To date, many studies showed the great benefits of switching from IV to PO antibiotics in some infectious diseases, especially skin and soft tissue, urinary tract, respiratory tract, gallbladder, and biliary tract infection. Higher level of evidence is necessary to confirm the benefit of early switching protocol in infectious condition management. Therefore, we conducted a clinical trial to investigate the effectiveness and cost of IV-to-PO antibiotic switch therapy in some surgical infection conditions.

Full description

Introduction: The benefit of early switching from intravenous (IV) to oral (PO)was raising from the last decade. This randomized clinical trial was to evaluate the effect of early switching from IV to PO antibiotics on the outcome of surgical patients at a public hospital.

Methods: Patients admitted for a therapeutic antibiotic to orthopedic and general surgery conditions were randomly assigned to three groups: control (non-switching), early switching (within 48-72 hours), and late switching (after 72 hours). The rate of effectiveness of each arm, length of hospital stay, length of IV antibiotics, and cost were recorded prospectively.

Enrollment: 210 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• on the second day of IV antibiotic
• no difficulties on taking oral medication
• clinical improvement

Exclusion criteria

• n/a

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

210 participants in 3 patient groups

non-switching

No Intervention group

Description:

control group

IV-to-PO conversion within 48-72 hours

Experimental group

Description:

early switching

Treatment:

Procedure: IV-to-PO conversion of antibiotics

IV-to-PO conversion after 72 hours

Experimental group

Description:

late switching

Treatment:

Procedure: IV-to-PO conversion of antibiotics