The Effect of Eggs on Postprandial Metabolism

Tufts University

Status: Completed

Conditions: Healthy

Treatments: Other: Eggs

Study type: Interventional

Funder types: Other

Identifiers

NCT01351207

IRB9795

Details and patient eligibility

About

The objective of this randomized, double-blinded, placebo-controlled, 3-way crossover pilot study is to determine whether eggs can favorably alter biomarkers of postprandial metabolism when included with other cooked breakfast foods typically selected by older Americans.

Enrollment: 20 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men & postmenopausal women, aged 50-70 years
• BMI 28-34 kg/m2

Exclusion criteria

• Cigarette smoking and/or nicotine replacement use
• Individuals taking estrogen
• Use of cholesterol-lowering medications
• Use of blood pressure-lowering medications
• Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements)
• Cardiovascular (heart) disease
• Gastrointestinal disease
• Kidney disease
• Endocrine disease: including diabetes, untreated thyroid disease
• Rheumatoid arthritis
• Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
• Systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 95 mmHg
• Regular use of oral steroids
• Regular daily intake of ≥ 2 alcoholic drinks
• Vegetarians
• Allergy to eggs
• Avoidance and/or intolerance of pork products
• No dietary supplements, including those containing any vitamins, minerals,herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 3 patient groups, including a placebo group

pork sausages and hash brown potatoes plus eggs

Active Comparator group

Treatment:

Other: Eggs

pork sausages and hash brown potatoes plus egg-free pudding

Placebo Comparator group

Treatment:

Other: Eggs

pork sausages and hash brown potatoes

Placebo Comparator group

Treatment:

Other: Eggs