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The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients

C

Chulalongkorn University

Status and phase

Unknown
Phase 4

Conditions

Continuous Ambulatory Peritoneal Dialysis

Treatments

Drug: Enalapril plus Losartan
Drug: Enalapril
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

A prospective, randomized, open-label, Single-center clinical trial to determine whether Enalapril or Enalapril plus Losartan effect on Peritoneal membrane transportation.

Full description

Detailed description:

Many peritoneal dialysis patients suffer from uremia due to inadequate dialysis or volume overload caused by failure of peritoneal membrane transport.One of the most important etiologies of peritoneal membrane failure are unavoidable to use high glucose-containing dialysate solution that induce injury to mesothelial cell.Previous data found that injured mesothelial cell produces Angiotensin (Ang) II to induce peritoneal inflammation and fibrosis. Blockade of the renin-angiotensin system by angiotensin-converting enzyme inhibition(ACEI) or angiotensin receptor antagonism (ARB) play a major role to slow this effect.

Although many trials in animal study have proved the benefit of ACEI and ARB in peritoneal membrane transport but clinical evidences in human are controversy. Up to now, all previous trials have limitation. First,The trials have small number of population(less than 20 in prospective randomized controlled trial). Second, The trials have multiple confounders on the study population because of the study include old case (that on peritoneal dialysis for many years) and new case (that just start treatment less than 1 year). Third, short duration of study(less than 3 months) to see the significant effect of RAAS blockade on peritoneal membrane transport. Forth, most study use dialysate albumin loss as an index of peritoneal membrane transport ,that less sensitivity to predict peritoneal membrane function. Fifth,no previous trials are attempted to study the effect of combination between ACEI and ARB. Therefore,we design to study the effect of both ACEI and ARB in a larger number of population, only in new case which are just recently found to be on peritoneal dialysis, our study is taken in longer duration and use both modified peritoneal equilibrium test and dialysate CA125 as an index of peritoneal membrane (physiology and anatomic index).This research will demonstrate efficacy of Enalapril and Losartan on Peritoneal membrane transportation lead to improve quality of life in CAPD patients.

Enrollment

90 estimated patients

Sex

All

Ages

20 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. All patients received CAPD more than 1 months but less than 1 year
  2. Subjects of either sex, more than 20 years old
  3. Hypertension
  4. Provision of written informed consent by subject or guardian

Exclusion criteria

  1. No history of taking an ACE inhibitor or angiotensin-receptor blockers or aldosterone antagonist for at least 2 month
  2. Serum potassium more than 5.5 mEq/L
  3. History of renal artery stenosis
  4. Peritonitis or volume overload within the preceding 1 month
  5. Myocardial infarction within the preceding 6 months or clinically significant valvular disease or any active cardiovascular disease
  6. History of malignant hypertension or hypertensive encephalopathy or cerebrovascular accident within the preceding 6 months
  7. Any condition that may have precluded a patient from remaining in the study, such as alcohol or drug abuse, chronic liver disease, malignant disease, or psychiatric disorder
  8. History of allergy or intolerance to an ACE inhibitor or ARB
  9. Hypotension defined as systolic blood pressure less than 90 mmHg

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

90 participants in 3 patient groups, including a placebo group

Enalapril
Active Comparator group
Treatment:
Drug: Enalapril
Enalapril plus Losartan
Active Comparator group
Treatment:
Drug: Enalapril plus Losartan
Control
Placebo Comparator group
Description:
Drug: antihypertensive agents, except ACE inhibitors and ARBs and spironolactone. Administration of antihypertensive agents will select as follows : CCB→β-blocker→α-blocker--\>hydralazine
Treatment:
Drug: Placebo

Trial contacts and locations

1

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Central trial contact

Talerngsak Kanjanabuch, Assist. Prf.

Data sourced from clinicaltrials.gov

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