The Effect of Entonox on Stages of Labor in Nulliparous Women

Rajavithi Hospital

Status: Completed

Conditions: ENTONOX; Nulliparous; Duration of Labor

Treatments: Drug: Entonox; Drug: Not receive Entonox

Study type: Interventional

Funder types: Other

Identifiers

NCT04321642

071

Details and patient eligibility

About

This Trial study about The effect of Entonox associated with duration of labor in Active phase and efficacy for relief pain of labor .So investigators start to study up to 14 months

Full description

Investigators will enroll participants in 2 groups by randomized . First group will inhale Entonox and the second group not receive any gas . The participants in Entonox group will inhale gas in 4-5 times for each uterine contraction and Nurse will measure blood pressure , O2 saturation ,pain score before use gas . The outcome,investigators study about Apgar score , duration of labor , pain relief in both group,route of delivery and estimated blood loss

Enrollment: 80 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nulliparity
• Age 18 years old or more
• Gestational age 37-40+6 wks
• Singleton
• Cephalic presentation
• Cervical dilatation > 5 cm
• Estimated fetal weight 2,500-4,000 gm

Exclusion criteria

• Estimated fetal weight more than 4,000 gm
• High risk pregnancy (Hypertension in pregnancy ,Endocrine disorder , autoimmune disorder , epilsepsy etc)
• SpO2 < 95 %
• Contraindication for Entonox usage ( Severe head injury , asthma , Pulmonary disease,Otitis media )
• Drug allergy : Metoclopramide , Dimenhydrinate , Pethidine ,Entonox

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Entonox

Experimental group

Description:

Inhalation Entonox in active phase of labor ( cervical dilatation more than 5 cm ) Inhaled Entonox before true uterine contraction in 30 sec , inhaled in 4-5 times for 1 contraction

Treatment:

Drug: Entonox

Not receive Entonox

Active Comparator group

Description:

Not receive any gas when archive in active phase of labor( cervical dilatation more than 5 cm )

Treatment:

Drug: Not receive Entonox