The Effect of Environmental Pollution on the Prognosis of Gastric Cancer

Chongqing Medical University

Status: Completed

Conditions: Gastric Cancers

Treatments: Diagnostic Test: gastric cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06686966

ZZ2024-292-01

Details and patient eligibility

About

Gastric cancer is one of the common malignant tumours worldwide, with a high incidence especially in East Asia. Although the occurrence of gastric cancer is closely related to genetic factors, lifestyle and dietary habits, in recent years, environmental pollution, especially air pollution, has received more and more attention as a potential carcinogenic factor. Numerous studies have shown that harmful substances in the air such as including passive smoking, soot and oil smoke exposure, incense burning exposure, occupational exposure and outdoor work, PM2.5, PM10, nitrogen oxides, sulphur dioxide, etc. may not only induce the occurrence of gastric cancer, but also affect the prognosis of gastric cancer patients. This experiment intends to determine the extent of the influence of air pollution on the prognosis of gastric cancer by analysing the survival data of gastric cancer patients in areas with different pollution levels. In addition, the association between air pollution levels and postoperative recurrence in gastric cancer patients was investigated to find possible mechanisms.

Enrollment: 3,400 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged ≥18 years;
• patients diagnosed with gastric cancer by pathological biopsy before surgery;
• patients without chemotherapy, radiotherapy, targeted and immunotherapy before enrolment;
• willing to participate in this study and sign the informed consent;
• complete clinical data.

Exclusion criteria

• patients with other primary malignant tumours other than gastric cancer;
• patients with systemic diseases such as severe cardiopulmonary insufficiency that affect the choice of treatment plan;
• patients who are not suitable for enrolment as assessed by the investigator;
• incomplete clinical data.