The Effect of Epidural Steroid Injections on Glycemic Control in Diabetic Patients According to the Doses of Steroids

Samsung Medical Center

Status: Completed

Conditions: Low Back Pain

Treatments: Other: caudal epidural steroid injection with Triamcinolone 20mg; Other: Selective transforaminal epidural block with triamcinolone 20 mg; Other: Selective transforaminal epidural block with triamcinolone 40 mg; Other: epidural steroid injection with Triamcinolone 40mg

Study type: Interventional

Funder types: Other

Identifiers

NCT01435707

2011-08-058

Details and patient eligibility

About

There has been no reports of the effect of various kinds of steroid or various dose of steroid which are commonly used in the clinical setting. Previous studies have simply shown that the blood glucose level is elevated in diabetes patients and did not show or suggest the adequate strategy of epidural steroid injection in diabetes patients regarding steroid type, dosage or injection interval. Therefore, the investigators tried to evaluate the effect of different dosage of triamcinolone, which is a commonly used steroid in epidural steroid injection, on the blood glucose level.

Full description

It is well known that blood glucose level is elevated in diabetes patients more than non-diabetes patients who underwent the epidural steroid injection. However, there has been no reports of the effect of various kinds of steroid or various dose of steroid which are commonly used in the clinical setting. Previous studies have simply shown that the blood glucose level is elevated in diabetes patients and did not show or suggest the adequate strategy of epidural steroid injection in diabetes patients regarding steroid type, dosage or injection interval. Therefore, the investigators tried to evaluate the effect of different dosage of triamcinolone, which is a commonly used steroid in epidural steroid injection, on the blood glucose level.

Enrollment: 125 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subjects who undergo epidural steroid injection (caudal epidural injection or selective transforaminal block) in the pain medicine outpatient clinic
• subjects older than 20 yrs.

Exclusion criteria

• ASA (American society of Anesthesiologists class) III or more
• severe cardiopulmonary disease or brain disorder
• Subjects diagnosed uncontrolled diabetes with complications
• subjects undergoing hormone therapy
• subjects with active infection
• subjects with pregnancy
• subjects with recent stress condition such as surgery or trauma
• subjects with active neurologic disorder
• those with anticoagulation therapy

Trial design

125 participants in 4 patient groups

Caudal 40 group

Experimental group

Description:

subjects who undergo caudal epidural block with triamcinolone 40 mg

Treatment:

Other: epidural steroid injection with Triamcinolone 40mg

STE 20 group

Experimental group

Description:

subjects who undergo selective transforaminal block with triamcinolone 20 mg

Treatment:

Other: Selective transforaminal epidural block with triamcinolone 20 mg

Caudal 20 mg

Experimental group

Description:

subjects who undergo caudal epidural block with triamcinolone 20 mg

Treatment:

Other: caudal epidural steroid injection with Triamcinolone 20mg

STE 40 group

Experimental group

Description:

subjects who undergo selective transforaminal block with triamcinolone 40 mg

Treatment:

Other: Selective transforaminal epidural block with triamcinolone 40 mg