The Effect of Erythromycin on Occurrence of Leaks From Cervical Esophageal-Gastric Anastomosis After Trans-Hiatal Esophagectomy

Kaplan Medical Center

Status: Unknown

Conditions: Postoperative Complications; Esophagectomy

Treatments: Drug: intravenous (IV) administration of erythromycin

Study type: Interventional

Funder types: Other

Identifiers

NCT00373919

erythro-esophagus

Details and patient eligibility

About

Cervical anastomotic leak is one of the most common complications after trans-hiatal esophagectomy.

Hypothesis: An early post operative administration of a pro-kinetic dosage of erythromycin will reduce leak occurrence.

Design: This is a prospective, randomized, double blind, placebo controlled study.

Number of patients: 30.

Inclusion Criteria:

• Patients after trans-hiatal esophagectomy

Exclusion Criteria:

• Allergy to erythromycin
• Use of phenothiazine
• QT prolongation
• Liver function test (LFT) abnormalities
• Myasthenia gravis
• Cardiomyopathy

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients after trans-hiatal esophagectomy

Exclusion criteria

• Allergy to erythromycin
• Use of phenothiazine
• QT prolongation
• Liver function test (LFT) abnormalities
• Myasthenia gravis
• Cardiomyopathy