The Effect of Erythropoietin at the Time of Reperfusion in Acute Myocardial Infarction

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Acute Myocardial Infarction

Treatments: Drug: human recombinant erythropoietin

Study type: Interventional

Funder types: Other

Identifiers

NCT00882466

EPO in AMI

Details and patient eligibility

About

The purpose of this study is to investigate the effect of intravenous human recombinant erythropoietin on the reperfusion injury at primary percutaneous coronary intervention in patients with acute myocardial infarction.

Enrollment: 58 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute myocardial infarction <12hr
• Age >18yrs
• First myocardial infarction
• culprit lesion : proximal to mid left anterior descending artery
• Baseline coronary flow : TIMI Grade 0~1

Exclusion criteria

• Patients with previous myocardial infarction
• History of thrombotic complication
• History of cerebral infarction
• Uncontrolled hypertension
• Increased hemoglobin level >17g/dL
• Patients with mechanical valve
• Cardiogenic shock

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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58 participants in 2 patient groups

PCI only

No Intervention group

Description:

primary PCI only

EPO

Experimental group

Treatment:

Drug: human recombinant erythropoietin