The Effect of Esmolol on Clinical Prognosis of Patients With Severe Sepsis

Fujian Provincial Hospital

Status: Completed

Conditions: Severe Sepsis

Treatments: Drug: natural saline; Drug: Esmolol

Study type: Interventional

Funder types: Other

Identifiers

NCT02794025

K2010-001-01

Details and patient eligibility

About

The purpose of this study was to investigate the effect of esmolol on hemodynamic parameters,tissue perfusion and the clinical prognosis of patients with severe sepsis

Full description

enrollment:151 patients

Inclusion criteria: (1) age > 18 years; (2) severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock, who (3) mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg; and (4) satisfactory sedation and analgesic treatment, with HR > 100 bpm.

Enrollment: 151 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years;
• severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock,
• mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg;
• satisfactory sedation and analgesic treatment, with HR > 100 bpm.

Exclusion criteria

• pre-existing cardiac dysfunction, valvular heart disease, high-degree atrioventricular block;
• acute or chronic pulmonary heart disease;
• a history of serious asthma;
• chronic renal insufficiency;
• cancer, autoimmune diseases, or contraindications for placement of deep venous catheter;
• insulin-dependent diabetes.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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151 participants in 2 patient groups

esmolol group

Experimental group

Description:

patients in the esmolol group received continuous infusion of esmolol via a micro-pump through a catheter placed in the superior vena cava.

Treatment:

Drug: Esmolol

control group

Sham Comparator group

Description:

Control group also received natural saline via a micro pump, in the same way the esmolol group received esmolol.

Treatment:

Drug: natural saline