The Effect of Exenatide on Fasting Bile Acids

Capital Medical University

Status: Completed

Conditions: Type 2 Diabetes Mellitus in Obese

Treatments: Drug: Exenatide treatment

Study type: Observational

Funder types: Other

Identifiers

NCT04303819

20131212

Details and patient eligibility

About

Newly diagnosed T2DM participants without hypoglycemic drugs intake were retrospective analyzed. Plasma total bile acids in fasting state (FTBAs) and other parameters were compared before and after exenatide treatment and correlation analysis between changes of FTBAs and glycemic parameters.

Full description

Newly diagnosed T2DM participants without hypoglycemic drugs intake were retrospective analyzed. Plasma total bile acids in fasting state (FTBAs) and other parameters were tested at baseline. Then exenatide were applied to the T2DM participants for 12 weeks. FTBAs and glycemic parameters were measured again after exenatide treatment, and correlation analysis between changes of FTBAs and glycemic parameters were conducted to investigate the role of BAs in the glycemic control effect of exenatide.

Enrollment: 38 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Newly diagnosed T2DM patients

Exclusion criteria

• History of hepatobiliary or pancreatic diseases
• History of anti-diabetic drugs intake
• Change of anti-dyslipidemia therapy regimen
• Estimated glomerular filtration rate less than 60 mL/min/1.73 m^2
• Pregnancy

Trial design

38 participants in 1 patient group

newly diagnosed T2DM participants

Description:

newly diagnosed T2DM participants without anti-diabetic drugs intake

Treatment:

Drug: Exenatide treatment