The Effect of Exercise and/or Diet on Health Related Parameters

Atlantis Medical University College

Status: Completed

Conditions: Overweight and Obesity

Treatments: Other: Exercise; Other: Normal Diet; Other: LCHF Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT04100356

AMUC-NIH-LCHF-P3-2014

Details and patient eligibility

About

The study evaluates the effect of exercise and/or diet during on body weight, body composition and health related blood parameters. Participants are overweight sedentary females, allocated to four different groups: Normal diet, Low-carb-high-fat diet, Normal diet + exercise, Low-carb-high-fat diet + exercise.

Full description

Diet and exercise can both be efficient tools to reduce bodyweight, get healthier body composition and improve many different health related blood parameters such as cholesterol and glucose tolerance.

Exercise has superior effect on skeletal muscle in the context of glucose tolerance, but adherence to exercise program can be a huge challenge for overweight individuals. While exercise has profound effect on metabolic health, diet has been superior when it comes to weight reduction. Previous studies have shown that 5-7% weight loss can improve glucose tolerance, measured as reduced fasting glucose and reduced 2-hour post prandial glucose.

We wish to see if the combination exercise and diet is superior to diet only when it comes to over all health.

Enrollment: 57 patients

Sex: Female

Ages: 33 to 47 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women
• Sedentary
• Premenopausal
• Caucasian
• BMI 26.9 - 36.1
• Age 33-4
• Living close to, or in Oslo.

Exclusion criteria

• Pregnancy
• Breast-feeding
• Smoking or tobacco use
• Previous medical history of cardio-vascular disease (CVD)
• Previous medical history of diabetes
• Previous medical history of endocrine disorder
• Previous medical history of kidney disease
• Use of lipid lowering medication
• Use of diabetes medication

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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57 participants in 4 patient groups

Normal diet

Experimental group

Description:

The group ingests normal diet, recommended by the health authorities

Treatment:

Other: Normal Diet

LCHF diet

Experimental group

Description:

The group ingests LCHF diet, a modified Atkins diet with 70 energy percentage fat

Treatment:

Other: LCHF Diet

Normal diet + exercise

Experimental group

Description:

The group ingests normal diet, recommended by the health authorities in addition to exercise program 3x week.

Treatment:

Other: Normal Diet

Other: Exercise

LCHF diet + exercise

Experimental group

Description:

The group ingests LCHF diet, a modified Atkins diet with 70 energy percentage fat, in addition to exercise program 3x week.

Treatment:

Other: LCHF Diet

Other: Exercise