The Effect of Exercise and Presleep Nutrition on Muscle Connective Tissue Remodelling

University of Toronto

Status

Enrolling

Conditions

Interventional

Treatments

Dietary Supplement: Carbohydrate Placebo

Dietary Supplement: Collagen and Vitamin C

Study type

Interventional

Funder types

Other

Identifiers

NCT06054620

CVC

Details and patient eligibility

About

The primary objective of this study will be to determine the influence of a presleep vitamin C-enriched, collagen-modelled supplement (CVC) on the metabolic fate of dietary glycine using a [2H5]glycine tracer within the intramuscular connective tissue at rest and after a bout of resistance exercise. Other outcomes will be related to regulation collagen remodelling in skeletal muscle.

Enrollment

12 estimated patients

Sex

All

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy, recreationally active, male and female participants.
Healthy will be defined as someone who does not have a health condition that would compromise their ability to safely participate in the strenuous physical activity involved in our study as screened for by the Get Active Questionnaire.
Willing to abstain from resistance exercise for 2 weeks prior to the first metabolic trial and for the duration of the study.
Participants must be able to abstain from lower-body resistance and/or plyometric exercise for at least 2 weeks prior to the first metabolic trial.
Participants will be aged 18-35 years old.
Participants must be normal to overweight (e.g., BMI 18.5-30).
Participants are willing to abide by the compliance rules of this study (e.g., abstain from physical activity and alcohol 48h prior to each trial).
Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).

Exclusion criteria

Inability to adhere to any of the compliance rules judged by principal investigator or medical doctor.
Self-reported regular tobacco use.
Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.).
Regular use of anti-inflammatory drugs (e.g., ibuprofen).
Self-reported regularly sleeping less than an average of 7 hours over 3 days (minimum recommended daily amount).
Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
Use of birth control and discontinued use in the last 3-months (female only).