The Effect of Exercise on Mood After Traumatic Brain Injury

University of Washington

Status: Completed

Conditions: Traumatic Brain Injury; Depression

Treatments: Behavioral: No exercise; Behavioral: Aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00571545

H133A020508

22868-B

Details and patient eligibility

About

We proposed to examine the effect of an aerobic exercise intervention on depression in persons with Traumatic Brain Injury (TBI). We will compare persons with chronic brain injury who are assigned to receive the exercise intervention with those in the control group to determine the effect of exercise on levels of depression and specific symptoms related to depression including anxiety, pain, sleep, and cognition. In addition, the effect of exercise on activity, participation level, and quality of life will be examined.

HYPOTHESES:

1. Participation in an aerobic exercise intervention will decrease the severity of depression in persons with chronic TBI.
2. Participation in an aerobic exercise intervention will lead to improvements in negative symptoms associated with depression including anxiety, insomnia, pain, and impaired cognitive functioning.
3. Participation in an aerobic exercise intervention will be related to improvements in activity and participation for patients with TBI.
4. Participation in an aerobic exercise intervention will lead to improvements in perceptions of quality of life.

Enrollment: 78 patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Traumatic brain injury 1-5 years prior to enrollment
• Current depression as measured by a score of 5 or greater on the depression portion of the Physician Health Questionnaire (PHQ).
• Sufficient cognitive ability to maintain participation in the study
• Sufficient English language ability to allow participation without an interpreter

Exclusion criteria

• Current suicidal ideation with intent or plan
• Currently pregnant
• History of significant cardiovascular or respiratory disease
• History of significant cardiovascular or respiratory disease
• Physical barriers to the use of standard aerobic exercise equipment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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78 participants in 2 patient groups

1

Experimental group

Description:

Subjects recruited from the community with a history of traumatic brain injury were enrolled into a 10 week supervised exercise program and encouraged to exercise at home as well.

Treatment:

Behavioral: Aerobic exercise

2

Other group

Description:

Controls were wait-listed for the supervised exercise program but were not treated during the 10 week wait period.

Treatment:

Behavioral: No exercise