The Effect of Exercise on Myokine Production in Aging Persons (EXI-AGE)

Hasselt University

Status: Enrolling

Conditions: Aging; Exercise

Treatments: Procedure: Percutaneous muscle biopsy; Procedure: Blood sample; Behavioral: Questionnaire; Other: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT05571709

B1152022000006

Details and patient eligibility

About

The incidence of age-related diseases, such as cancer and cardiovascular diseases, rapidly rises. These days, age-related diseases cause the majority of all healthcare expenses. During ageing senescent cells secrete a range of harmful inflammatory signals, which leads to chronic inflammation (inflamm-aging) and accelerates aging throughout the rest of the body. Interestingly, people who regularly exercise show less signs of inflamm-aging compared to people with a sedentary lifestyle. Molecules secreted by skeletal muscles, called myokines, may play an important role. However, the underlying molecular mechanisms remain unknown. This pilot study aims to investigate if an acute bout of resistance training is an appropriate tool to induce an increase in the release of muscle derived myokines in aged persons.

Enrollment: 20 estimated patients

Sex: All

Ages: 65 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy persons

Exclusion criteria

• Smoking

• Infection < 2 weeks ago

• Received a vaccine < 2 weeks ago

• Allergy to Lidocain

• Immune deficiency

• Presence of a tumour or in treatment

• Usage of anti-coagulant medication

• Presence of following conditions:

  • Haemophilia
  • Auto-immune disease
  • Cardiovascular disease
  • Musculoskeletal diseases which refrains the patient from exercising

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Aged individuals who perform exercise training

Active Comparator group

Description:

Aged individuals will perform an acute bout of resistance trainig (30 minutes). This training is focused on the lower limbs.

Treatment:

Procedure: Percutaneous muscle biopsy

Behavioral: Questionnaire

Procedure: Blood sample

Other: Exercise training

Aged individuals who stay sedentary

Sham Comparator group

Description:

Aged individuals will remain seated for 30 minutes.

Treatment:

Procedure: Percutaneous muscle biopsy

Behavioral: Questionnaire

Procedure: Blood sample