The Effect of Exercise on Peripheral Blood Gene Expression in Angina

NHS Foundation Trust

Status

Completed

Conditions

Angina Pectoris

Treatments

Behavioral: Structured exercise training

Study type

Interventional

Funder types

Other

Identifiers

NCT01147952

STH15565

Details and patient eligibility

About

Regular exercise is known to produce significant health benefits and to reduce the risk of heart diseases, although how this benefit occurs is not well understood. White blood cells are known to be involved in triggering heart attacks, and which genes are switched on or off in white blood cells determines whether they have beneficial or harmful effects. Previous studies, and studies ongoing in our group, have demonstrated measurement of peripheral blood gene expression (which reflects white blood cell gene expression) is able to distinguish between patients with and without coronary artery disease, or patients who are able to develop good compared with poor coronary collateral arteries. Therefore, the gene expression signature in peripheral blood may provide novel diagnostic or prognostic information, and insight into the pathogenesis of heart disease.

We therefore hypothesise that exercise alters peripheral blood gene expression in patients with coronary artery disease and angina. This will identify possible ways that exercise improves angina and reduces the risk of heart disease.

Enrollment

60 patients

Sex

All

Ages

30 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Class I to III angina pectoris (classified according to the Canadian Cardiovascular Society [CCS])with documented myocardial ischemia or coronary artery disease on angiography
Ability to read and speak English to a level allowing satisfactory completion of written questionnaires and to understand instruction during the exercise programme.

Exclusion criteria

Acute coronary syndromes or recent myocardial infarction (<2 months)
Left main coronary artery stenosis >25% or high-grade proximal left anterior descending artery stenosis
Known reduced left ventricular function (ejection fraction <40%)
Significant valvular heart disease
Insulin-dependent diabetes mellitus
Occupational, orthopedic, and other conditions that preclude regular exercise
Patients whose ECG prevents interpretation of an exercise test (LBBB, RBBB, pacemaker implantation).
Patients who already perform greater than 30min continuous exercise three times weekly (self-reported).