The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Frederiksberg University Hospital

Status: Completed

Conditions: Muscle Strength

Treatments: Other: Non-painful control injections; Other: Experimental knee pain

Study type: Interventional

Funder types: Other

Identifiers

NCT01346995

072.07

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Enrollment: 36 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged between 20 to 35 years
• healthy
• untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion criteria

• symptomatic musculoskeletal diseases
• history of traumatic injuries to muscles, tendons or joints of the lower extremity
• knee joint pain within a month prior to enrollment

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

Experimental Knee Pain

Experimental group

Description:

Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad

Treatment:

Other: Experimental knee pain

Control

Active Comparator group

Description:

non-painful injections of isotonic saline into the infrapatellar fatpad.

Treatment:

Other: Non-painful control injections