The Effect of Feeding Length on the Oxygenation Instability Among Premature Infants

Rambam Health Care Campus

Status: Completed

Conditions: Respiratory Disease; Premature Infant

Treatments: Procedure: Bolus feeding; Procedure: Continuous gavage feeding

Study type: Interventional

Funder types: Other

Identifiers

NCT03748472

Feeding length and oxygenation

Details and patient eligibility

About

SpO2 instability is in the nature of premature infants. Hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. Different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. Premature infants are fed via an NG/OG tube. Feeding length might influence the oxygenation instability among premature infants therefore the aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when are fed over 30 min vs over 2 hours, as documented by SpO2 histograms.

Enrollment: 24 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Premature Infants (GA<37weeks) on non-invasive respiratory support (CPAP, NIPPV, HFNC) Feeding>100 ml/kg/day

Exclusion criteria

Congenital anomalies e.g. gastroschesis, congenital diaphragmatic hernia, cyanotic heart disease.

Instability because of:

Acute lung pathology for example x-ray confirmed pneumonia, air leak Active culture proven sepsis Need for inotropic support for low blood pressure

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Bolus feeding

Experimental group

Treatment:

Procedure: Bolus feeding

continuous gavage feeding

Experimental group

Treatment:

Procedure: Continuous gavage feeding