The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients

Ankara University

Status: Completed

Conditions: Acute Kidney Injury; Laparoscopic Colorectal Surgery

Treatments: Other: pulse variability index

Study type: Interventional

Funder types: Other

Identifiers

NCT03408834

15-823-16

Details and patient eligibility

About

This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in renal ischemic injury, was used.

Full description

Our object in this study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatine in renal ischemic injury, was used.

Patients undergoing elective laparoscopic colorectal surgery, 18 to 75 years old, planned surgery duration longer than 2 hours, were included in this study. Patients were divided into 2 groups with respect to their fluid resuscitation, Group 1: goal directed fluid therapy via PVI monitoring Group 2: conventional fluid resuscitation. Blood samples were drawn from both groups for NGAL measurement before CO2 insufflation (T0), and at 6th(T1) and 12th(T2) hours after CO2 insufflation. At the end of the surgery, sugammadex was given to all patients for reversal of muscular blockade.

Enrollment: 29 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• laparoscopic surgery
• obese patient

Exclusion criteria

• patient refusal
• major comorbidity
• renal failure
• diabetes mellitus

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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29 participants in 2 patient groups, including a placebo group

pulse variability index

Active Comparator group

Description:

fluid management performed by pulse variability index

Treatment:

Other: pulse variability index

conventional fluid management

Placebo Comparator group

Description:

fluid management performed by conventional fluid management

Treatment:

Other: pulse variability index