The Effect of Fluticasone/Salmeterol Combination on Exertional Breathlessness in Patients With Mild COPD

Queen's University

Status

Completed

Conditions

COPD

Treatments

Drug: placebo

Drug: fluticasone/salmeterol combination

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00559312

SCO110755

Details and patient eligibility

About

Even patients with milder COPD can have significant physiological abnormalities which become more pronounced during exercise, leading to intolerable breathing discomfort (dyspnea). While there is a compelling physiological rationale for the efficacy of inhaled corticosteroid/long-acting bronchodilator combination therapy [i.e., fluticasone 250μg/salmeterol 50μg (FSC250/50)] in moderate to severe COPD, little information is available on the potential impact of this therapy in milder symptomatic disease. This study will be the first to explore mechanisms of dyspnea and activity limitation in milder COPD and will determine if there is a sound physiological rationale for the use of FSC as therapy for this subpopulation.

Enrollment

18 patients

Sex

All

Ages

41+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stable mild COPD,
FEV1/FVC<0.7 and FEV1>60% predicted,
Activity-related dyspnea (i.e., Baseline Dyspnea Index focal score <9, MRC dyspnea scale >2),
Cigarette smoking history ≥20 pack-years.

Exclusion criteria

Presence of a significant disease other than COPD that could contribute to dyspnea and exercise limitation,
Important contraindications to clinical exercise testing,
Use of daytime oxygen,
History of Asthma.