The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects

Leiden University Medical Center (LUMC)

Status: Completed

Conditions: Calorie Restriction; Aging

Treatments: Other: No stimuli of food smell and vision; Other: Stimuli of food smell and vision

Study type: Interventional

Funder types: Other

Identifiers

NCT01243879

P08.077

Details and patient eligibility

About

Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster. The investigators hypothesize that visual and odorous food stimuli impact the neuroendocrine and metabolic response to starvation in healthy humans.

In this randomized cross-over intervention study 12 healthy, young men will fast twice for 60-hours in the presence or absence of food-related visual and odorous stimuli. At baseline and on the last morning of each intervention an oral glucose tolerance test (OGTT) will be performed. During the OGTT blood is sampled and hypothalamic neuronal activity is measured by functional MRI.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Caucasian male volunteers
• Age > 18 years and < 70 years
• Body mass index (BMI) > 20 kg/m2 and < 25 kg/m2
• Fasting serum glucose (FSG) < 6.1 mmol/L

Exclusion criteria

• Any significant chronic of hereditary disease (including renal, hepatic or endocrine disease)
• Any significant abnormal laboratory results found during the medical screening procedure
• Any use of medication (except for NSAID)
• Anosmia or any other (acquired) loss of olfaction (ea. rhinitis)
• Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
• Difficulties to insert an intravenous catheter
• Smoking
• MRI contraindications
• Recent blood donation (within the last 3 months)
• Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Fasting with stimuli

Active Comparator group

Description:

Fasting in the presence of food-related stimuli

Treatment:

Other: Stimuli of food smell and vision

Fasting without stimuli

Sham Comparator group

Description:

Fasting in the absence of food-related stimuli

Treatment:

Other: No stimuli of food smell and vision