The Effect of Food Supplements on Food Intake and Gut Hormone Levels

Queen Mary University of London

Status: Completed

Conditions: Endocrine; Obesity; Obesity; Appetite; Perverted

Treatments: Dietary Supplement: Lauric Acid, Perilla Oil and Diindolylmethane

Study type: Interventional

Funder types: Other

Identifiers

NCT04292236

QMREC2018/20

Details and patient eligibility

About

When a meal is eaten, nutrients activate the release of hormones from the bowel into the blood stream. Normally there is a large amount of hormone released, which tells the brain that an individual is full and to stop eating. When people gain weight and become overweight or obese, these hormone signals are reduced, resulting in these people eating more and gaining more weight. This study is investigating mechanisms which may break this cycle by using particular nutrients to restore reduced hormone levels.

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Obese but otherwise healthy volunteers,
• body mass index (BMI) of 30-40 kg/m2
• agreement to consume scheduled meals
• ability to understand the study information sheet and instructions in English and able to provide informed consent.

Exclusion criteria

• Not meeting any of the exclusion criteria above.
• Major gut surgery
• Major health problems
• Taking medication for diabetes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Administered at time 0 min and 300 min. Cellulose was used as the placebo.

Treatment:

Dietary Supplement: Lauric Acid, Perilla Oil and Diindolylmethane

Dietary Supplement

Active Comparator group

Description:

Administered at 0 min and 300 min. Combination of lauric acid, perilla oil and diindolylmethane was used as the dietary supplement.

Treatment:

Dietary Supplement: Lauric Acid, Perilla Oil and Diindolylmethane